IDEXA360 Safety & Risk Information
Medications to Be Cautious With
Certain medications, especially those prescribed for type 1 or type 2 diabetes—such as insulin or sulfonylureas like Glucotrol XL or Amaryl—may interact with compounded tirzepatide. Because this medication can slow down how quickly your stomach empties, it might affect how well oral medications are absorbed. Always consult your healthcare provider about how to time your doses appropriately.
Other medications in the GLP-1 or GIP class, such as Wegovy®, Ozempic®, Mounjaro®, Zepbound®, Saxenda®, Victoza®, Byetta®, and Bydureon®, should not be used simultaneously with compounded tirzepatide. Additionally, be cautious if using other weight-loss aids, including supplements, and always disclose them to your provider.
Important Medical History to Disclose
It’s essential to share your full medical background with your provider before beginning treatment. Make sure to mention if you’ve ever had:
– Type 1 or type 2 diabetes
– Pancreatitis
– Kidney issues
– Diabetic eye complications
– Thyroid cancer
– Depression or mood disorders
– Suicidal thoughts or tendencies
Pregnancy and Breastfeeding Considerations
– During Pregnancy: Compounded tirzepatide is not advised. Animal research suggests it may pose a risk to the developing fetus. Additionally, weight loss during pregnancy is not recommended and may be harmful.
– Planning a Pregnancy: If you could become pregnant, stop using compounded tirzepatide at least two months before trying to conceive, as it remains in the body for an extended time.
– While Breastfeeding: Tirzepatide has been found in the milk of lactating animals. Its safety in breastfeeding humans is not established, so its use is not recommended during this time.
Potential Risks of Withholding Information
Failing to fully and honestly disclose your medical history or current prescriptions could lead to serious health risks, including death.
Serious Side Effects to Watch For
While many side effects are mild—such as nausea, fatigue, or digestive upset—others may require immediate medical attention:
– Thyroid Tumors
– Pancreatitis
– Gallbladder Issues
– Hypoglycemia
– Kidney Damage
– Allergic Reactions
– Diabetic Retinopathy
– Increased Heart Rate
– Mental Health Changes
Sharing and Medication Safety
Never share syringes, needles, or vials with others, as this increases the risk of infection.
Avoid using more than one GLP-1/GIP medication at the same time. If you are already using a similar treatment, provide documentation including dosage details. Taking multiple related medications can heighten the risk of adverse effects.
Using Compounded Tirzepatide Safely
Before starting treatment:
– Inform your provider if you’re using diabetes medications, including insulin.
– If you’re on oral contraceptives, be aware that absorption might be reduced.
Your provider will guide you on proper use. Typically:
– The medication is injected once weekly.
– Rotate injection sites.
– Oral versions available (3–6 mg daily; micro-dosing possible).
Questions to Discuss with Your Provider
– Do you have a history of pancreas or kidney problems?
– Are you currently taking medications for diabetes?
– Have you experienced diabetic eye complications?
– Are you pregnant, nursing, or planning to become pregnant?
– Are you using any over-the-counter drugs, vitamins, or supplements?
Legal Notice
Compounded tirzepatide is not approved by the U.S. Food and Drug Administration (FDA). The FDA does not review compounded drugs for safety or effectiveness. All brand names mentioned are trademarks of their respective companies.
Need Medical Help?
If you experience a medical emergency, dial 911 or seek immediate medical care. Side effects can be reported to the FDA through their MedWatch program at 1-800-FDA-1088 or online at www.fda.gov/medwatch.
